We found that Neferine alone inhibited cells migration/invasion abilities (Supplementary Fig. S1, p < 0.01, respectively), and promoted HCC epithelial cells HepG2 and Bel-7402 to more epithelial phenotype by increasing E-cadherine expression and decreasing Vimentin/N-cadherin/Snail expression (Supplementary Fig. S2). The gene discussed is CDH2; the disease is hepatocellular carcinoma.