In triplicate experiments, the mean GI50 (±95% CI) for THZ1 and THZ1-R in our panel of PTCL cell lines were 390±26 nM and 5365±360 nM, respectively (P<0.0001, T-test, Supplementary Fig. 1c), suggesting that CDK7 could be a relevant target in PTCLs. Here, CDK7 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.