PRKCA and neoplasm: Cholestatics (chlorpromazine; cyclosporine A) destabilize intercellular TJs via reactive oxygen species-mediated effects on TJ-associated F-actin distribution in human hepatic HepaRG cells2, 3, whilst the tumour-promoter, phorbol ester, a specific protein kinase C-alpha (PKCα) activator, reduces TJ integrity and ablates cell polarity in HepG2 cells4, 5.