INS and diabetes mellitus: Nonetheless, it is worthwhile to mention that in the studies by Arita et al. and Villarino et al. [15, 20], administration of insulin minimized the effects of DM and increased the rate of orthodontic tooth movement to that of non-diabetic mice, which suggests that if diabetic patients have their blood glucose levels controlled, orthodontic tooth movement will be insignificantly affected by DM.