In fact, Grant et al. [12] reported that several SNPs within intronic regions of TCF7L2, including the rs7903146 (C>T), show significant associations with T2DM, and these findings have been replicated by numerous groups, demonstrating the rs7903146 (C>T) SNP as one of the most important T2DM susceptibility variants. The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.