In this regard, the aim of this study was to investigate the relationship between clinical parameters in GDM and variants in genes involved with nutrients and metabolism (namely, TCF7L2, PPARG2, PPARGC1A, carbohydrate metabolism; FTO, MC4R, APOA5, LDLR, GCKR, fat metabolism; MTHFR, folate metabolism). The gene discussed is PPARGC1A; the disease is gestational diabetes.