Administration of LiCl to pregnant female mice carrying Wnt2 knockout embryos at ED8-10, led to a drastic increase in the survival rate of Wnt2 knockout offspring, an elevation of Lef1 expression in the posterior SHF, restoration of SHF cell proliferation, and a rescue of the AVSD phenotype [25]. The gene discussed is WNT2; the disease is familial atrioventricular septal defect.