BRCA2 and breast carcinoma: High-risk women include women with a known BRCA1 or BRCA2 mutation and their first-degree relatives, women with a lifetime risk of 20–25% or greater for breast cancer, and women with a history of chest irradiation between the ages of 10 and 30 [5]. Between 9,000 and 18,000 new diagnoses of breast cancer per year in the United States are associated with a genetic predisposition of which greater than 60% is due to a BRCA1 or BRCA2 mutation.