NFE2L2 and obesity due to melanocortin 4 receptor deficiency: The molecular mechanisms which account for the DNA-protective properties of EGCG involve scavenging of radicals that are typical for obesity [57] which has been found in vivo in rodents and also in vitro [58, 59] alternatively; indirect effects caused by activation of antioxidant enzyme via the transcription factors nuclear factor erythroid 2-related factor 2 (Nrf2) may play a role [60]