A recent review with twenty three case-control studies focusing on the role of oxidative stress in PC patients also demonstrated increased oxidative stress profiles and impairment of antioxidant defense systems in PC patients, concluding that oxidative biomarkers MDA and 8OH-dg as well as antioxidant parameters SOD, CAT, GSH enzyme family, and vitamins C and E may be potentially predictive biomarkers of PC [49]. The gene discussed is GSS; the disease is pachyonychia congenita.