ABCG2 and intrahepatic cholestasis: Our previous study indicated that CBS treatment had a beneficial effect on 17α-ethynylestradiol- (EE-) induced intrahepatic cholestasis rats and significantly increased the mRNA and protein expressions of multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP), both important proteins on the apical membrane of hepatocytes involving in the transport of bile acids, bilirubin, drugs, and so on [9].