The latter samples provide data for the first time from T2D subjects: interestingly, both STARD10 and ARAP1 expression were decreased in T2D islets versus non-diabetic controls, the former in common with earlier findings,73 and further suggesting that STARD10 depletion may impair insulin production in the diseased state. This evidence concerns the gene ARAP1 and type 2 diabetes mellitus.