Focusing on the role played by factors controlling oxidative mechanisms in the pathophysiology of migraine we described a striking correlation between the rs4880 variant of the superoxide-dismutase 2 (SOD2) gene (associated with reduced antioxidant activity) and the presence of unilateral cranial autonomic symptoms in patients affected by migraine with aura[4]. The gene discussed is SOD2; the disease is migraine with aura.