Finally, we excluded any correlation between polymorphisms rs4818 and rs4680 of Catechol-O-Methyltransferase (COMT) gene and migraine, suggesting to look over COMT to explain catecholamine derangement in migraine, exploring enzymes involved in catecholamines synthesis and catabolism such as monoamine-oxidase, dopamine beta hydroxylase, tyrosine hydroxylase or tyrosine decarboxylase[6]. The gene discussed is COMT; the disease is migraine disorder.