We showed previously that hypertension in SHR, linked to chromosome 4 in recombinant inbred and congenic strains, is, in part, caused by renal Cd36 deficiency, as a component of the overall metabolic syndrome abnormalities encoded by SHR Cd36 (Aitman et al., 1999; Neckar et al., 2012; Pravenec et al., 1999, 2008). This evidence concerns the gene CD36 and hyperinsulinemic hypoglycemia, familial, 4.