Further exploration of the chromosome 4 linkage by expression analysis and congenic mapping identified Cd36 as the major determinant of SHR hypertension and insulin resistance in this chromosomal region, a result followed by the demonstration of associations between CD36, hypertension and related metabolic traits in mice and humans (Aitman et al., 1999; Corpeleijn et al., 2006; Farook et al., 2012; Love-Gregory et al., 2008, 2011; Pietka et al., 2014; Wilson et al., 2016). This evidence concerns the gene CD36 and hypertensive disorder.