MDM2 and lung adenocarcinoma: MDM2 cleavage products were generated in a strictly Caspase-2-dependent fashion and became detectable by immunoblotting when A549 lung adenocarcinoma cells underwent mitosis in the presence of the spindle assembly checkpoint (SAC) inhibitor reversine, targeting MPS1 kinase (Fig. 1A; Supplemental Fig. S1C,D; Santaguida et al. 2010).