Conceivably, the induction of centrosome amplification in mouse models can suffice to accelerate cancer onset in the absence of p53 (Coelho et al. 2015; Serçin et al. 2016), but evidence for the lack of such an effect also exists (Kulukian et al. 2015; Vitre et al. 2015). The gene discussed is TP53; the disease is cancer.