MTOR and glycogen storage disease II: This study is the first attempt to systematically analyze mTOR signaling pathway in Pompe disease, an inherited deficiency of lysosomal acid alpha‐glucosidase, in which the primary defect—intralysosomal glycogen accumulation—leads to numerous secondary abnormalities including defective autophagy, aberrant mitochondria and calcium homeostasis, and severe muscle wasting (reviewed in Lim et al2014).