MTOR and adult Fanconi syndrome: A more recent study demonstrated downregulation of mTOR and defective lysosomal localization of this kinase after starvation/refeeding in proximal tubular cell lines from Ctns−/− mice, a model of cystinosis, an LSD and the most common cause of renal Fanconi syndrome in children (Gahl et al, 2002; Andrzejewska et al, 2016).