Reduced basal mTOR activity was shown in several LSDs: in brain and cerebellar cells from Cln3Δex7/8 knock‐in mice, a model of Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) and in JNCL patient's lymphoblastoid cells (Cao et al, 2006); in NPC1‐ and NPC2‐knockdown endothelial cells (Xu et al, 2010); in Drosophila pupae lacking the TRPML1 homologue (transient receptor potential mucolipin 1), the protein involved in mucolipidosis IV (MLIV; Wong et al, 2012); in a human podocyte model of Fabry disease, a deficiency of lysosomal α‐galactosidase A (Liebau et al, 2013). This evidence concerns the gene MCOLN1 and Fabry disease.