Diabetic KK-A [52], leptin-resistant (db/db) [53, 54] and leptin-deficient (ob/ob) [55, 56], high fat [9] and high fructose [57] diet-fed mice all of which exhibit hepatic steatosis, have all been reported to demonstrate impeded regeneration after hepatectomy or CCL4 administration. This evidence concerns the gene CCL4 and Hepatic steatosis.