Furthermore, TM4SF1 in breast cancer cells couples the collagen I receptor tyrosine kinase DDR1 to the syntenin 2, a cortical adaptor, and further PKCα that promotes phosphorylation and activation of JAK2 and STAT3 for cancer stem cell traits and metastatic reactivation in the metastatic sites such as lung, bone, and brain [8]. The gene discussed is TM4SF1; the disease is cancer.