NOS3 and coronary artery disorder: Previously published reports have suggested a relationship between the occurrence of ISR or CAD and genetic variation occurring as single nucleotide polymorphisms (SNPs) in the endothelial nitric oxide synthase gene (eNOS) [11–13], the angiotensin converting enzyme gene (ACE) [14], the angiotensin II type 1 receptor gene (AT1R) [15,16], TGF-β [17–19], and VEGF [20,21].