As this result is consistent with MST1 eQTLs in liver and adipose tissues (but not whole blood), we believe that one possible mechanism of action of this genetic polymorphism alters expression and translation of MST1 in certain tissues (e.g. liver and adipose), which in turn results in changes of serum levels of the MST1 protein, and ultimately leading to increased risk of IBD. Here, MST1 is linked to inflammatory bowel disease.