However, when compared to all the SLiM-binding hepatocyte surface proteins and their binding partners in the human PPI network, the identified HCV-targeted protein complexes were shown to be significantly enriched in KEGG pathways belonging to the functionality of cell entry (P = 3.7 × 10−2) and carcinogenesis (P = 2.7 × 10−2), but not infectious disease (P = 3.8 × 10−1) (see S8 Fig). Here, PROS1 is linked to infectious disease.