F2 and Thrombocytopenia: Percutaneous nephrolithotomy, on the other hand, may be contraindicated or should be performed with extra care in patients presenting with bleeding diathesis (disseminated intravascular coagulopathy, severe thrombocytopenia, or prolonged prothrombin and partial thromboplastin times), cardiopulmonary insufficiency resulting in aggravation of respiratory symptoms when placed in a prone position, severe spinal dysraphism, and other causes of an abnormal body habitus, ectopic kidneys, and retrorenal colon.