Recently, Ener et al. evaluated the oxidative stress status and antioxidant capacity in patients with painful bladder syndrome, and used serum total antioxidant capacity, total oxidant status, binding capacity of exogenous cobalt to human albumin, serum advanced oxidation protein products, paraoxonase, arylesterase, IgE, and C-reactive protein as oxidative markers (17). This evidence concerns the gene CRP and interstitial cystitis.