On the basis of the joint-effect analysis via RadvizTM the top projection identified, when considering four proteins (IL-21, IL-10, ACE, and MCP-1/CCL2) simultaneously, had a 79.6% accuracy to correctly classify patients indicating that separation can be obtained for four retinal diseases using simple protein-signatures (Fig. 2). The gene discussed is IL21; the disease is Abnormal retinal morphology.