Since PVRL cases may present with severe vitreous opacities preventing clear retinal examination, an accurate AqH test – such as the IL-10, IL-21, ACE triad – could discriminate between the differential diagnosis of INIU, PVRL and RRD (with AMD in this case serving as a negative control), contributing to early diagnosis and treatment thereby avoiding visual loss and improving prognosis. This evidence concerns the gene IL10 and age-related macular degeneration.