Many previous studies have suggested that the modulation of NF-κB activity is crucially important for effectively treating respiratory diseases involving pulmonary inflammation, because NF-κB plays a major role in the inflammatory responses of bronchial epithelial cells to various pathogens and toxic environmental factors such as bacteria, viruses, dust mite allergen, cigarette smoke, diesel particles, and dust29, 30, 31, 32, 33, 34. This evidence concerns the gene NFKB1 and respiratory system disorder.