We chose two cell lines of the two main histotypes of esophageal cancer, esophageal adenocarcinomas (EACs) and esophageal squamous cell carcinomas (ESCCs), which are characterized by divergent overexpression of the two targeted receptors, EGF-receptor (EGFR) and HER2. This evidence concerns the gene ERBB2 and esophageal squamous cell carcinoma.