Importantly, among HCC-bearing mice, a higher proportion of Klrk1+/+ than Klrk1−/− mice (50% versus 33.3%) displayed a grade 3 HCC — the most advanced lesion based on histology (Fig. 1f,g; Supplementary Table 1) This phenotype confirms the advanced tumour burden (tumour size and liver/body weight ratio (Fig. 1b,d) observed in Klrk1+/+ mice. This evidence concerns the gene KLRK1 and neoplasm.