During tumour development, the function of NKG2D-expressing cells is likely to evolve over time, depending on (i) the composition of the inflammatory microenvironment, (ii) the level of expression of cell surface/soluble ligands and (iii) the expression level of NKG2D which can be reduced upon sustained triggering, consequently leading to the desensitization of NK cells13, 18, 47. This evidence concerns the gene KLRK1 and neoplasm.