CCR2 and neoplasm: CCR2, a chemokine receptor preferentially involved in monocytes trafficking to inflamed tissues and that defines their differentiation into pro-inflammatory macrophages31, was significantly more expressed in the tumours from Klrk1+/+ than Klrk1−/− mice (Fig. 7e) implying a better recruitment of circulating monocytes and/or macrophages in the presence of NKG2D.