We evidenced a drastic enrichment in CD8+T cells (Fig. 2a,c,f)—but not NK or NKT cells (Fig. 2b,d–f)—in HCC-bearing WT mice, with average CD8+T cell numbers of 1.5 × 106 cells in the surrounding tissue and 7.7 × 105 in the tumour, compared with 2.9 × 105 cells per gram of tissue in livers from AMC mice (Fig. 2f). This evidence concerns the gene CD8A and hepatocellular carcinoma.