ADIPOQ and Insulin resistance: Consistent with the previous study23, A-FABP KO mice exhibited an improved metabolic profile as indicated by the significant alleviation of HFD-induced glucose intolerance and insulin resistance (Supplementary Fig. 1f–h), a markedly reduced serum insulin and glucose levels, lipid profiles and a significantly higher adiponectin level compared with WT controls (Supplementary Fig. 1i–m).