In this study, we revealed that miR‐30c was a key regulator of EMT in DN by targeting Snail1, and over‐expression of miR‐30c attenuated EMT in TECs as well as the profibrogenic microenvironment, and finally ameliorated renal tubulointerstitial fibrosis and dysfunction in DN. Here, SNAI1 is linked to liver dysplastic nodule.