It is thought that increased circulating adipocytokines such as TNF-α, IL-6, leptin, resistin, plasminogen activator inhibitor-1, and acute-phase reactants such as C-reactive protein could have an important role in the development of MetS and/or its components and its association with disease activity in SLE patients [12–15]. This evidence concerns the gene RETN and systemic lupus erythematosus.