The haplotype combinations for three TLR3 SNPs (rs1879026, rs5743313, and rs5743314) and their genotypic distribution within the two comparative studies (patients with HCV diagnosed with cirrhosis compared to patients with chronic HCV) were established to determine the linkage disequilibrium (LD) pattern and the frequency of the haplotypes. This evidence concerns the gene TLR3 and Cirrhosis.