The TLR3 SNP rs5743314 that was previously described to be associated with risk for cirrhosis was also found to be associated with the risk for chronic HCV-related end-stage liver disease progression (rs5743314 GC genotype: OR = 1.545, 95% CI = 1.022–2.334, and p value = 0.0383), also the dominant model of rs5743314 associated with HCV liver disease progression (OR = 1.523, 95% CI = 1.021–2.271, and p value = 0.0385) (Table 5). Here, TLR3 is linked to Cirrhosis.