Several studies have shown that genetic variations in the TLR3 gene are associated with susceptibility and/or resistance to numerous infectious and immune diseases [12], including acquired immune deficiency syndrome (AIDS) [13, 14], hepatitis B viral (HBV) infection [15], liver diseases in HCV-infected patients [16], predisposition to tick-borne encephalitis [17], human herpes simplex virus type 2 (HHV-2) infection [18], cutaneous candidiasis [19], autoimmunity [19], and type 1 diabetes mellitus [20]. Here, TLR3 is linked to AIDS.