IFNG and chronic rhinosinusitis with nasal polyps: CRSwNP is generally characterized by type 2 inflammation with pronounced eosinophilia and the presence of high levels of IL-5 and IL-13 in Western countries, while neutrophilic and proinflammatory cytokines have been reported to be predominant in Chinese patients with nasal polyps [3], specifically in those patients who were IL-5/IL-17/IFN-gamma negative [4].