Baseline production of epithelial cytokines was not different between epithelial cells derived by nasal polyps and epithelial cells derived by ostiomeatal mucosa of patients with CRSsNP (TSLP: 0.76 ± 0.48 pg/ml versus 0.61 ± 0.48 pg/ml; IL-25: 0.13 ± 0.07 pg/ml versus 0.18 ± 0.07 pg/ml; IL-33: 2.25 ± 1.26 pg/ml versus 2.56 ± 1.27 pg/ml, resp). Here, IL33 is linked to chronic rhinosinusitis without nasal polyps.