Adiponectin also directly inhibits tumor necrosis factor-alpha (TNF-a), which plays a role in tumor cell proliferation and angiogenesis (recent studies have shown that HPs may lie in the classic adenoma-carcinoma sequences and have demonstrate special molecular changes and genetic mutations which correlated with hyperplastic polyps or/and serrated colonic polyps which represent mixed feature of colonic adenomas and HPs) [25–27]. Here, TNF is linked to carcinoma.