Another issue that should be considered is that ACE, in addition to angiotensin II, has other potential substrates, some of which influence dopaminergic neurotransmission (and are proposed to be associated with MS), such as substance P and neurotensin (Binder, Kinkead, Owens, & Nemeroff, 2001; Krasnova, Bychkov, Lioudyno, Zubareva, & Dambinova, 2000; Soltys, Knight, Scharf, Pitt, & Mao‐Draayer, 2014; Vilisaar et al., 2015). The gene discussed is NTS; the disease is myeloid sarcoma.