Our data are consistent with findings showing no association between the risk for nicotine dependence and the ACE‐I/D polymorphism among healthy individuals from the Czech Republic and German populations (Baghai et al., 2008; Hubacek et al., 2004), as well as with a negative report on the association between this polymorphism and number of cigarettes smoked per week among healthy controls from the Czech Republic (Hubacek et al., 2004). Here, ACE is linked to nicotine dependence.