Inconsistent with the findings of previous studies, our study demonstrated that the protective effects of BZA on cardiomyocyte hypertrophy can be blocked by the PPAR-α antagonist rather than the PPARβ/δ and PPAR-γ inhibitor, implying that BZA attenuates cardiac hypertrophy via PPAR-α. Here, PPARD is linked to cardiac hypertrophy.