RELN and autism spectrum disorder: Patients suffering from psychiatric disorders such as schizophrenia, bipolar disorder, major depression, and autism spectrum disorders (ASDs) exhibit an approximate reelin downregulation of 50% in several brain structures, most notably the hippocampus and PFC (Impagnatiello et al., 1998; Guidotti et al., 2000; Folsom and Fatemi, 2013).