For instance, the distances between the C-terminal of mutated IL-7Rα homodimer in T cell and B cell in acute lymphocytic leukemia (ALL) patients are less than 30 Å, which spontaneously activate the IL-7 signaling pathway to malignant proliferation of lymphocyte in absence of IL-7 [8, 19]. This evidence concerns the gene IL7R and acute lymphoblastic leukemia.