FOSL2 and systemic sclerosis: The inhibition of H3K27me3 by 3-deazaneplanocin (DZNep) stimulates the release of collagen, induces the profibrotic transcription factor fos-related antigen 2 (FRA-2), and exacerbates the fibrosis induced by transforming growth factor β (TGFβ) in cultured SSc fibroblasts [105].