In univariate analysis, high CACNA1B (Cav2.2) expression (HR, 2.701, 95% CI: 1.797–4.061; P < 0.001), male (HR, 1.530, 95% CI: 1.070–2.188; P = 0.020), large tumor size (3 cm) (HR, 2.064, 95% CI: 1.431–2.976; P < 0.001), high histopathology grading (HR, 0.419, 95% CI: 0.306–0.574; P < 0.001), lymph node metastasis (HR, 1.482, 95% CI: 1.005–2.185; P = 0.047), smoking (HR, 2.237, 95% CI: 1.365–3.666; P = 0.001), and advanced TNM stage (HR, 1.425, 95% CI: 1.108–1.833; P = 0.006) were significantly associated with overall survival. This evidence concerns the gene CACNA1B and metastatic malignant neoplasm in the lymph nodes.