Similar to white, we reasoned that albino might map to a locus associated with albinism in other amphibians37,38, including axolotl39, and so focused our efforts on tyr and oca2. tyr encodes an enzyme that functions in melanin synthesis while oca2 encodes an integral membrane protein that functions to maintain melanosomal pH40,41. The gene discussed is TYR; the disease is albinism.