A recent systematic review of APP prevalence between 1970 and 2009 found in a sample of 1,418,163 patients with mental disorder (82.9% with a diagnosis of schizophrenia) a median APP prevalence of 19.6% across different geographical regions, ranging from 6% to 90%, with higher median prevalence in Asia (32%) and Europe (23%) compared with North America (16%) and Oceania (16.4%) [18]. This evidence concerns the gene APP and schizophrenia.