PRDX2 and colorectal carcinoma: In our current study, over-expression of PRDX2 in CRC was identified and confirmed by several lines of evidence, including assessment of PRDX2 mRNA and protein expression in CRC cell lines compared with those in HCEC, comparative determination of PRDX2 expressions in six matched CRC lesions and adjacent noncancerous tissues, and a clear demonstration of generally high level of PRDX2 expression in a relatively large number of 226 paired CRC specimens and noncancerous colorectal tissues.