As noted above, among the DM+DE genes passing our stringent statistical criteria are examples associated with biological processes relevant to endometriosis pathogenesis and progression such as immune responses (TGFBR1), neurogenesis (BDNF), cell proliferation (JAZF1) progesterone responses (ORS2, HAND2, SGK1), and cell signaling (DAPK1). The gene discussed is HAND2; the disease is endometriosis.