These three proteins are, however, widely expressed by a variety of epithelial tissues, and so we next set out to examine the functional relationship between prostasin and the HAIs in different types of epithelial cells, including LNCaP prostate cancer cells, HaCaT immortalized human keratinocytes, and 184 A1N4 mammary epithelial cells. This evidence concerns the gene PRSS8 and prostate cancer.