AICDA and B-cell chronic lymphocytic leukemia: Similarly, for IGHV3-21 stereotyped subset #2, two of four sites identified are AGC Serine codons at overlapping AID hotspots, with codon 32 being within an AGCT motif and codon 34 within an AGCA, although in the case of IGHV3-21 the mutations are commonly seen in non-stereotyped CLL also [50].