TLR4 and peripheral neuropathy: Furthermore, studies have reported sensitisation of DRG primary sensory neurons in PTX-induced peripheral neuropathy through induction of monocyte chemoattractant protein-1(MCP-1/CCL2) and its receptor CCR2, as well as toll-like receptor 4 (TLR-4) signalling in the DRG via MAP kinases and NFkB [21–23].