Although the corresponding functions of these mRNAs in active TB remain largely unknown, based on other data, we can find that they are mainly involved in cell proliferation (CHRM3), protein ubiquitination (RNF175), genetic susceptibility (HLA-DQB1), antibody function (FCGR1A, FCGR1B), T-cell homeostasis (FAM198B) and promoter activity (TPM1) [29,30]. This evidence concerns the gene RNF175 and tuberculosis.