Although SRF has been described to interact with several other transcription factors [23], two groups of co-factors are known to directly control its transcriptional specificity and activity: myocardin-related transcription factors (myocardin, MRTF-A–also known as megakaryoblastic leukemia/myocardin-like 1 or MKL1—and MRTF-B) and ternary complex factors (ELK-1, SAP-1 and NET) [24]. Here, MRTFA is linked to adult acute megakaryoblastic leukemia.