Concerning the crucial role of Cav-1 in glucose and fatty acid metabolism, and the clinical significance of GDM induced-macrosomia, our study highlights the importance of Cav-1 in placental glucose and fatty acid transports via AMPK signaling pathway, to investigate the role of Cav-1 in GDM induced-macrosomia and provide a new perspective on prevention and treatment of GDM induced-macrosomia. This evidence concerns the gene CAV1 and gestational diabetes.