It has been recently shown that the number of CD8+/NFATc2+ T cells is increases in the lungs of COPD patients compared to controls and that NFAT inhibition with either cyclosporine or calcium-release activation calcium channels inhibitor (syntax-66) produces greater anti-inflammatory effects on COPD CD8+ cells than corticosteroids [37]. This evidence concerns the gene CD8A and chronic obstructive pulmonary disease.