In an independent human endotoxemia protocol, the GENE Study,[30, 32] which administered a higher dose of LPS than the FFAME Study (1ng/kg LPS), we examined expression of S100A8, S100A9 and S100A12 pre- and post-LPS in adipose tissue (n = 25), and CD14+ monocytes (n = 15) of healthy individuals (n = 11 overlapped both tissues). This evidence concerns the gene S100A8 and serum lipopolysaccharide activity.