There was ~4-fold higher expression in individuals with n-3 PUFA intake >2g/day compared with those consuming <1g/day (S100A8, logFC = 1.92, adj p = 0.038; S100A9, logFC = 2.49, p = 0.027) consistent with a role for n-3 PUFA in enhancing expression in adipose tissue in the chronic inflammatory state of obesity. The gene discussed is S100A8; the disease is obesity due to melanocortin 4 receptor deficiency.